盐酸利莫那班[干冰运输]
Rimonabant hydrochloride
CAS: 158681-13-1
Molecular Formula: C22H21Cl3N4O.ClH
盐酸利莫那班[干冰运输] - Names and Identifiers
| Name | Rimonabant hydrochloride |
| Synonyms | ACOMPLIA Rimonabant HCl RIMONABANT HCL Rimonabant hcl Acomplia, SR141716 Rimonabant(Acomplia) ACOMPLIA (RIMONABANT RIMONABANT HYDROCHLORIDE Rimonabant hydrochloride RimonabantConsultedStandard N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-n-1-piperidinyl-1h-pyrazole-3-carboxamide monohydrochloride 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide monohydrochloride 1H-Pyrazole-3-carboxamide, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-, monohydrochloride |
| CAS | 158681-13-1 |
| EINECS | 233-720-0 |
| InChI | InChI=1/C22H21Cl3N4O.ClH/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15;/h5-10,13H,2-4,11-12H2,1H3,(H,27,30);1H |
盐酸利莫那班[干冰运输] - Physico-chemical Properties
| Molecular Formula | C22H21Cl3N4O.ClH |
| Molar Mass | 500.25 |
| Melting Point | 230-240°C |
| Boling Point | 627.6℃ at 760 mmHg |
| Solubility | DMSO: soluble20mg/mL, clear |
| Appearance | off-white to white crystalline powder |
| Color | white to beige |
| Storage Condition | 2-8°C |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Rimonabant could inhibit the growth of Mtb with an MIC of 54 μM. MmpL3, an anti-TB target, is the direct target of rimonabant. Rimonabant itself (10 -12 -10 -3 M, 12 concentrations) inhibits the basal binding of [ 35 S]GTPgS to human cortical membranes in a concentration dependent manner, with a -log IC 50 of 4.7±0.2 (IC 50 = 20 μM) and a maximal inhibition of 48±2%. |
| In vivo study | Rimonabant (10 mg/kg by gavage) is fed for 2 weeks to 3-month-old male obese Zucker rats as an impaired glucose tolerance model and for 10 weeks to 6-month-old male obese Zucker rats as a model of the metabolic syndrome. RANTES and MCP-1 serum levels are increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with Rimonabant, which slowes weight gain in rats with the metabolic syndrome. Neutrophils and monocytes are significantly increased in young and old obese vs lean Zucker rats and lowered by Rimonabant. Platelet-bound fibrinogen is significantly enhanced in obese vs lean Zucker rats of both age, and is reduced by Rimonabant . Rimonabant (20 mg daily) exhibits a significant reduction in many cardiometabolic risk factors. |
盐酸利莫那班[干冰运输] - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R36 - Irritating to the eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
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View History
盐酸利莫那班[干冰运输]
咪唑乙醇 标准品
3-氯丙醛二乙缩醛(含稳定剂碳酸钙)
(2-对甲苯噻唑-4-基)甲醇
(S)-2-((((9H-芴-9-基)甲氧基)羰基)氨基)-4-(3,4-二氟苯基)丁酸
5-[[(2R,3R,4R,5R,6R)-3-乙酰氨基-4,5-二乙酰氧基-6-(乙酰氧基甲基)-2-四氢吡喃基]氧基]戊酸
咪唑乙醇 标准品
3-氯丙醛二乙缩醛(含稳定剂碳酸钙)
(2-对甲苯噻唑-4-基)甲醇
(S)-2-((((9H-芴-9-基)甲氧基)羰基)氨基)-4-(3,4-二氟苯基)丁酸
5-[[(2R,3R,4R,5R,6R)-3-乙酰氨基-4,5-二乙酰氧基-6-(乙酰氧基甲基)-2-四氢吡喃基]氧基]戊酸